2017年5月30日 星期二

Humanized antibody, Keytruda/Pembrolizumab

Humanized antibodies are antibodies from non-human species whose protein sequences have been modified to increase their similarity to antibody variants produced naturally in humans.

Humanized antibody - Wikipedia

Pembrolizumab is a humanized antibody used in cancer immunotherapy. It blocks a protective mechanism on cancer cells, and allows the immune system to destroy those cancer cells. It targets the programmed cell death 1 receptor.Wikipedia
Molar mass146 kDa
ATC codeL01XC18 (WHO)
SourceHumanized (from mouse)
Trade nameKeytruda

眾所周知癌症是其中一種最難治癒的疾病,而且治療過程往往痛苦又漫長。過往癌症治療通常會根據腫瘤出現的位置去施藥,不過最近美國 Merck…

robot, robotics

Uh oh.
Stanford researcher says Tesla's autopilot feature doesn't recognize cyclists well enough to be trusted.
  1. the branch of technology that deals with the design, construction, operation, and application of robots.
    "civilian research on robotics is advancing swiftly"


Karen Handel, the Republican nominee in Georgia's Sixth Congressional District, at a watch party in Roswell last month for the first round of the special election.
'Narrowcast' Trump? Republicans Seek Formula to Keep House Majority


Conservatives are grappling with a question: Do candidates run with President Trump or against him? A little bit of both, some say, is needed.

BROADCAST VS 'Narrowcast'

2017年5月29日 星期一

One of electronica’s pioneers, Daphne Oram

She's the music pioneer you've probably never heard of. (BBC Culture)

One of electronica’s pioneers, Daphne Oram helped revolutionise music but remains surprisingly little known. A new play puts her offbeat life, and accomplishments, into the spotlight.

Fascist bloggers and musicians have expressed their liking for an 80s-obsessed variant of instrumental electronica
"I had my suspicions that music like this could be picked up in this way, it’s not surprising. This style contains a lot of cliches from the 80s, and I think the co-option by the far right comes from people thinking things were better 30 years ago. And it promotes body ideals.”

Fascist bloggers and musicians have expressed their liking for an 80s-obsessed variant of instrumental electronica

エレクトロニカ(英語 Electronica)とは、電子音楽や、電子音楽に影響を受けている音楽全般を包括的に表す言葉。ただし狭義に用いられることがある(後述)。

Electronica is an umbrella term that encompasses a broad group of electronic-based styles such as technohouseambientdrum and bassjungle, and industrial dance, among others.[1] It has been used to describe the rise of electronic music styles intended not just for dancing but also concentrated listening.[2]

2017年5月25日 星期四

titles face-out, not spine-out


No cash, just 3,000 titles and face-out, not spine-out – here's what it looks like.

Go inside Amazon's first New York City bookstore
On a rainy Thursday, Amazon — the e-commerce giant that began as an online bookstore in the 1990s — opened its first brick-and-mortar store in New York, in the same mall where book chain Borders shuttered its store in 2011…

the part of a book's jacket or cover that encloses the inner edges of the pages, facing outwards when the book is on a shelf and typically bearing the title and the author's name.

2017年5月14日 星期日

Bump: Ostpolitik

South Korean President Moon Jae-in will attemp to revive an updated version of the Sunshine Policy to improve ties with North Korea.

Ostpolitik - Wikipedia


Neue Ostpolitik (German for "new eastern policy"), or Ostpolitik for short, was the normalization of relations between the Federal Republic of Germany (FRG, or West Germany) and Eastern Europe, particularly the German Democratic Republic (GDR, or East Germany) beginning in 1969.

United Airlines Will Now Pay Voluntarily Bumped Passengers Up To $10,000

United Airlines promises to cut down on overbooking and raise the maximum incentive for passengers to skip a flight to $10,000.

Hon Hai Enjoys Big iPhone Bump

informal , chiefly US An increase:there was a bump in the number of outbound flights

  1. To deprive (a passenger) of a reserved seat because of overbooking.3 ((米俗))(予約を取りすぎて)〈人に〉搭乗予約を取り消す.

2017年5月12日 星期五

Proust Questionnaire

The Proust Questionnaire is a questionnaire about one's personality. Its name and modern popularity as a form of interview is owed to the responses given by the French writer Marcel Proust.

Proust Questionnaire - Wikipedia

Gwathmey Professor in Practice Peter Eisenman recently answered the Proust Questionnaire: http://archinect.com/…/the-proust-questionnaire-peter-eisen…
For this iteration of the Proust Questionnaire, we're talking with the noted theorist and architect Peter Eisenman, who reflects on having not written a book, disliking Scandinavian buildings, and Charlie Brown. With this one, we…

optics, orbit, alpha male gamesmanship/ SWAGGER

"Any move that might bring him more money or, now, more power, Trump will make – regardless of the ethics or the optics or the damage to his reputation. He is shameless."

ince Melissa McCarthy's instantly classic portrayal of White House Press Secretary Sean Spicer on last weekend’s "Saturday Night Live” (if you’re among the few who hasn’t yet seen it, click below), I haven’t been able to watch Spicer without laughing.
Apparently Trump isn’t laughing, though. According to a Trump ally quoted in Politico, Trump "doesn't like his people to look weak."
But it’s not just weakness. For all his alpha male swagger, Trump is particularly sensitive to attacks by women -- from Megyn Kelly’s questions during the debates, to the millions who marched the day after his inauguration, to Meryl Streep's take-down at the recent Golden Globes. Women seem to get under Trump’s thin skin. And Trump’s counterattacks -- mocking their looks, claiming they're "overrated," suggesting they have their periods – make him seem even weirder than usual.
I hear Rosie O'Donnell, Trump’s longtime nemesis, has volunteered to play Steve Bannon on SNL. Go for it, Rosie.
When it comes to bullies, satire is the best disinfectant. For alpha male bullies, satire by a woman is sheer poison.
What do you think?

White House press secretary Sean Spicer (Melissa McCarthy) and secretary of education nominee Betsy DeVos (Kate McKinnon) take questions…

"First, there was the unseemly haste. May’s eagerness to be the first foreign leader to shake that short-fingered hand, the scramble to catch up with Nigel Farage and Michael Gove, gave off a strong whiff of desperation.
That is a scent Trump understands. What he lacks in book smarts, he makes up for in alpha male gamesmanship."

Sure, it went fine – Trump managed not to drop any bombshells. But this hasty visit smacks of desperation

And while Band, a longtime aide to Bill Clinton, never worked for State, he also held multiple roles within the Clintons' orbit. As Eric Lichtblau of The New York Timesrecently explained it to NPR:

"He is a personal assistant to Bill Clinton. He ran a consulting company that paid Bill Clinton a lot of money until 2012. He is also the head of Clinton's Global Initiative which gets together muckety mucks from all over the world for big charity events, and he's with the Clinton Foundation. So to figure out at any one time which hat someone like Doug Band is wearing when he communicates with aides to Hillary Clinton is a bit of a puzzle."

There's no question the optics are bad for Clinton and the Clinton Foundation. But no proof has emerged that any official favors — regulations, government contracts, international deals — were curried in exchange for donations or pledges.


Pronunciation: /ˈɒptɪks/ 


1The scientific study of sight and the behaviour of light, or the properties of transmissionand deflection of other forms of radiation.
2chiefly North American (Typically in a political context) the way in which an event or course of action is perceived by the public:the issue itself is secondary to the optics of the Democrats opposing this administration in a high-profile way
More example sentences
  • They had no clue about the optics of the situation.
  • With a federal election on the horizon, optics are everything.
  • However the optics of such a venture are worrisome for McPhail.


Pronunciation: /ˈɔːbɪt/ 


1The regularly repeated elliptical course of a celestial object or spacecraft about a star or planet:the Earth’s orbit around the sun
1.1One complete circuit round an orbited body:the satellite will complete one orbit every 12 hours
1.2[MASS NOUN] The state of moving in an orbit:the earth is in orbit around the sun
1.3The path of an electron round an atomic nucleus.
2An area of activity, interest, or influence:audiences drawn largely from outside the Party orbit